PTCH1 Polyclonal Antibody

Background:
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Research Area: Cancer, Cell Biology, Neuroscience, Stem Cells

Synonyms:
PTC, BCNS, HPE7, PTC1, PTCH, NBCCS, PTCH11

Immunogen: Recombinant protein of human PTCH1

Swissprot: Q13635
Gene Accession: BC043542

Calculated MW: 161 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-6149/sc-6147/sc-9016

Citation(s):
https://pubmed.ncbi.nlm.nih.gov/31877414/