PTK6 (phospho-Y342) polyclonal, anti-human

Background:
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants.

Alternative Name:
Protein-tyrosine kinase 6, Breast tumor kinase, Tyrosine-protein kinase BRK, PTK6, BRK

Application Dilution:
IHC: 1:50~1:200

Specificity: PTK6 (phospho-Y342) polyclonal antibody detects endogenous levels of PTK6 protein only when phosphorylated at Tyr342.

Immunogen:
Synthetic phosphopeptide derived from human PTK6 around the phosphorylation site of Tyrosine342.

MW: ~ 52kDa

Swiss-Prot: Q13882

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.