PTMA polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60817
Background:
Prothymosinα(PTα) is a nuclear protein that iswidely expressed inmammalian tissues, including kidney, liver,spleen, normal lymphocytes, human T cell leukemia virus-infected T cells andmyeloma cells. The human PTα genemaps to chromosome 2 and encodes a protein that exhibits punctuated nuclear distribution,which correlatesto transcription sites. PTα is a chromatin-remodeling protein that was initially thought to mediate T lymphocyte maturation, but subsequently has been shown to be involved in cellcycle progression, proliferation and cell differentiation. PTα is thought to be transported into the nucleus bythe karyopherin β1-Rch-1 complex,where it associates with Histones H2A, H2B, H3 and H4. Also, PTα is phosphorylated on Thr 7 and Thr 12 or 13 by Prothymosin α-phosphorylating kinase (PTαK) in amitogen activating pathway. The amino terminus of PTα iscleaved to produce a secreted, biologically active peptide thymosin α1,whichmay be used as an immunomodulatorin cancer patients and patients with chronic active hepatitis, or as an immunoen hancer of vaccinesin immunocompromised individuals.
Alternative Name:
Prothymosin alpha, Cleaved into the following 2 chains, Prothymosin alpha, N-terminally processed, Thymosin alpha-1, PTMA, TMSA
Application Dilution: WB: 1:500~1:1000
Specificity: PTMA polyclonal antibody detects endogenous levels of PTMA protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PTMA.
MW: ~ 12 kDa
Swis Prot.: P06454
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Prothymosinα(PTα) is a nuclear protein that iswidely expressed inmammalian tissues, including kidney, liver,spleen, normal lymphocytes, human T cell leukemia virus-infected T cells andmyeloma cells. The human PTα genemaps to chromosome 2 and encodes a protein that exhibits punctuated nuclear distribution,which correlatesto transcription sites. PTα is a chromatin-remodeling protein that was initially thought to mediate T lymphocyte maturation, but subsequently has been shown to be involved in cellcycle progression, proliferation and cell differentiation. PTα is thought to be transported into the nucleus bythe karyopherin β1-Rch-1 complex,where it associates with Histones H2A, H2B, H3 and H4. Also, PTα is phosphorylated on Thr 7 and Thr 12 or 13 by Prothymosin α-phosphorylating kinase (PTαK) in amitogen activating pathway. The amino terminus of PTα iscleaved to produce a secreted, biologically active peptide thymosin α1,whichmay be used as an immunomodulatorin cancer patients and patients with chronic active hepatitis, or as an immunoen hancer of vaccinesin immunocompromised individuals.
Alternative Name:
Prothymosin alpha, Cleaved into the following 2 chains, Prothymosin alpha, N-terminally processed, Thymosin alpha-1, PTMA, TMSA
Application Dilution: WB: 1:500~1:1000
Specificity: PTMA polyclonal antibody detects endogenous levels of PTMA protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PTMA.
MW: ~ 12 kDa
Swis Prot.: P06454
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review