PTN Polyclonal Antibody

Background:
Pleiotrophin(PTN) also known asheparin-binding brain mitogen(HBBM) orheparin-binding growth factor 8(HBGF-8) orneurite growth-promoting factor 1(NEGF1) orheparin affinity regulatory peptide(HARP) orheparin binding growth associated molecule(HB-GAM) is aproteinthat in humans is encoded by thePTNgene.Pleiotrophin is an 18-kDagrowth factorthat has a high affinity forheparin. It is structurally related tomidkineandretinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.

Research Area: Cancer, Immunology, Neuroscience, Signal Transduction

Synonyms:
HARP, HB-GAM, HBBM, HBGAM, HBGF-8, HBGF8, HBNF, HBNF-1, HBNF1, heparin affin regulatory protein, Heparin binding growth associated molecule, Heparin binding growth factor 8, Heparin binding neurite outgrowth promoting factor 1, Heparin-binding brain mitogen, Heparin-binding growth factor 8, Heparin-binding growth-associated molecule, heparin-binding neurite outgrowth promoting factor, Heparin-binding neurite outgrowth-promoting factor 1, NEGF1, Neurite growth promoting factor 1, Neurite outgrowth-promoting factor, heparin-binding, OSF-1, OSF1, Osteoblast-specific factor 1, pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1), Pleiotrophin, PTN, PTN

Immunogen: Synthetic peptide of human PTN

Swissprot: P21246
Gene Accession: NP_002816

Calculated MW: 19 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-1394/sc-1395/sc-20716