BNIP-3 polyclonal, anti-human
€470.00
In stock
SKU
AC-AP73337
Background:
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Other Names:
BNIP3; NIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Antigen Type: synthetic peptide
Antigen Type: BNIP3 (HGNC:1084)
Gene ID: 664
Primary Accession: Q12983
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Other Names:
BNIP3; NIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Antigen Type: synthetic peptide
Antigen Type: BNIP3 (HGNC:1084)
Gene ID: 664
Primary Accession: Q12983
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