PTP kappa Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP8417a
Background:
PTPkappa, a member of the receptor class 2B subfamily of protein-tyrosine phophatases, is involved in regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. It forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTP-kappa. This Type I membrane protein, localized at adherens junctions, is found at high levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. It contains 4 fibronectin type III domains, 1 immunoglobulin-like C2-type domain, 1 MAM domain, and 2 protein-tyrosine phosphatase domains.
Other Names:
Receptor-type tyrosine-protein phosphatase kappa, Protein-tyrosine phosphatase kappa, R-PTP-kappa, PTPRK, PTPK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8417a was selected from the N-term region of human PTPkappa . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PTPRK
Gene ID: 5796
Primary Accession: Q15262
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
PTPkappa, a member of the receptor class 2B subfamily of protein-tyrosine phophatases, is involved in regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. It forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTP-kappa. This Type I membrane protein, localized at adherens junctions, is found at high levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. It contains 4 fibronectin type III domains, 1 immunoglobulin-like C2-type domain, 1 MAM domain, and 2 protein-tyrosine phosphatase domains.
Other Names:
Receptor-type tyrosine-protein phosphatase kappa, Protein-tyrosine phosphatase kappa, R-PTP-kappa, PTPRK, PTPK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8417a was selected from the N-term region of human PTPkappa . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PTPRK
Gene ID: 5796
Primary Accession: Q15262
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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