PTP1B polyclonal, anti-human, mouse

Background:
The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is a reversible process, involving both enzymes that phosphorylate proteins on tyrosine residues as well as a rapidly expanding family of protein tyrosine phosphatases. These latter enzymes bear little resemblance to either the protein serine and protein threonine phosphatases or to the acid and alkaline phosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein. On the basis of sequence analysis, PTP1B (PTPase 1B) expressed in human placenta exhibits similarities both with the common leukocyte antigen (CD45) and with LAR, a homolog of the neural adhesion molecule (NCAM). PTP1B is synthesized as a 435 amino acid precursor protein which is cleaved to generate the active 321 amino acid enzyme.

Alternative Name:
PTP-1B, PTPN1, PTP1B, PTP1B, Non receptor tyrosine phosphatase 1, Protein phosphotyrosylphosphatase 1B, Protein tyrosine phosphatase 1B, Protein tyrosine phosphatase non receptor type 1, Protein tyrosine phosphatase placental, Protein-tyrosine phosphatase 1B, PTN1, PTP 1B, PTP-1B, PTPN 1, PTPN1, Tyrosine protein phosphatase non receptor type 1, Tyrosine-protein phosphatase non-receptor type 1,

Application Dilution:
WB:1:1,000-1,5,000
ICC:1:500-1:2,000
IHC:1:100-1:500

Specificity: PTP1B polyclonal antibody detects endogenous levels of PTP1B protein.

Immunogen:
Recombinant protein

MW: 50 kDa

Swiss-Prot: P18031(Human) P35821(Mouse)

Purification & Purity:
Protein affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.