PTPA Polyclonal Antibody

Background:
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Signal transduction

Synonyms:
subunit B'', KIAA0044 , MGC2184 , Phosphotyrosyl phosphatase activator, PP2A, PP2A phosphatase activator , PP2A subunit B', PP2A subunit B' isoform PR53, PP2A subunit B' PR53 isoform , PPP2R4, PR53 , PR53 isoform, Protein phosphatase 2, regulatory subunit B-prime, Protein phosphatase 2A activator regulatory subunit 4, Protein phosphatase 2A regulatory subunit B' (PR 53), PTPA, PTPA, Serine/threonine protein phosphatase 2A regulatory subunit B' , Serine/threonine-protein phosphatase 2A activator, Serine/threonine-protein phosphatase 2A regulatory subunit 4, Serine/threonine-protein phosphatase 2A regulatory subunit B''

Immunogen: Fusion protein of human PTPA

Swissprot: Q15257
Gene Accession: BC002545

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.84 mg/mL
Dilution: IHC 1:50-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.