PTPD1 polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP8424a
Catalog Number: AC-AP8424a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB0623-0624
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB0623-0624
Applications: IHC-P, WB
Datasheet
Request Information
Background:
PTPD1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
Other Names:
Tyrosine-protein phosphatase non-receptor type 21, Protein-tyrosine phosphatase D1, PTPN21, PTPD1
Target/Specificity:
This PTPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human PTPD1.
Antigen Region:
751-780
Antigen Type: Synthetic Peptide
Gene Name: PTPN21
Gene ID: 11099
Primary Accession: Q16825
NCBI Accession: NP_008970.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
PTPD1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
Other Names:
Tyrosine-protein phosphatase non-receptor type 21, Protein-tyrosine phosphatase D1, PTPN21, PTPD1
Target/Specificity:
This PTPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human PTPD1.
Antigen Region:
751-780
Antigen Type: Synthetic Peptide
Gene Name: PTPN21
Gene ID: 11099
Primary Accession: Q16825
NCBI Accession: NP_008970.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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