PTPN1 Blocking Peptide (Center)
€363.00
In stock
SKU
AC-BP20182C
Background:
The protein encoded by this gene is the founding member ofthe protein tyrosine phosphatase (PTP) family, which was isolatedand identified based on its enzymatic activity and amino acidsequence. PTPs catalyze the hydrolysis of the phosphate monoestersspecifically on tyrosine residues. Members of the PTP family sharea highly conserved catalytic motif, which is essential for thecatalytic activity. PTPs are known to be signaling molecules thatregulate a variety of cellular processes including cell growth,differentiation, mitotic cycle, and oncogenic transformation. ThisPTP has been shown to act as a negative regulator of insulinsignaling by dephosphorylating the phosphotryosine residues ofinsulin receptor kinase. This PTP was also reported todephosphorylate epidermal growth factor receptor kinase, as well asJAK2 and TYK2 kinases, which implicated the role of this PTP incell growth control, and cell response to interferon stimulation.
Other Names:
Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B, PTPN1, PTP1B
Target/Specificity:
The synthetic peptide sequence is selected from aa 236-249 of HUMAN PTPN1
Gene Name: PTPN1
Gene ID: 5770
Primary Accession: P18031
Other Accession: P20417; P35821; NP_002818.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is the founding member ofthe protein tyrosine phosphatase (PTP) family, which was isolatedand identified based on its enzymatic activity and amino acidsequence. PTPs catalyze the hydrolysis of the phosphate monoestersspecifically on tyrosine residues. Members of the PTP family sharea highly conserved catalytic motif, which is essential for thecatalytic activity. PTPs are known to be signaling molecules thatregulate a variety of cellular processes including cell growth,differentiation, mitotic cycle, and oncogenic transformation. ThisPTP has been shown to act as a negative regulator of insulinsignaling by dephosphorylating the phosphotryosine residues ofinsulin receptor kinase. This PTP was also reported todephosphorylate epidermal growth factor receptor kinase, as well asJAK2 and TYK2 kinases, which implicated the role of this PTP incell growth control, and cell response to interferon stimulation.
Other Names:
Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B, PTPN1, PTP1B
Target/Specificity:
The synthetic peptide sequence is selected from aa 236-249 of HUMAN PTPN1
Gene Name: PTPN1
Gene ID: 5770
Primary Accession: P18031
Other Accession: P20417; P35821; NP_002818.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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