PTPN2 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13311b
Background:
The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. Members of the PTPfamily share a highly conserved catalytic motif, which is essentialfor the catalytic activity. PTPs are known to be signalingmolecules that regulate a variety of cellular processes includingcell growth, differentiation, mitotic cycle, and oncogenictransformation. Epidermal growth factor receptor and the adaptorprotein Shc were reported to be substrates of this PTP, whichsuggested the roles in growth factor mediated cell signaling. Threealternatively spliced variants of this gene, which encode isoformsdiffering at their extreme C-termini, have been described. Thedifferent C-termini are thought to determine the substratespecificity, as well as the cellular localization of the isoforms.Two highly related but distinctly processed pseudogenes thatlocalize to distinct chromosomes have been reported. [provided byRefSeq].
Other Names:
Tyrosine-protein phosphatase non-receptor type 2, T-cell protein-tyrosine phosphatase, TCPTP, PTPN2, PTPT
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13311b was selected from the C-term region of PTPN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PTPN2
Gene ID: 5771
Primary Accession: P17706
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. Members of the PTPfamily share a highly conserved catalytic motif, which is essentialfor the catalytic activity. PTPs are known to be signalingmolecules that regulate a variety of cellular processes includingcell growth, differentiation, mitotic cycle, and oncogenictransformation. Epidermal growth factor receptor and the adaptorprotein Shc were reported to be substrates of this PTP, whichsuggested the roles in growth factor mediated cell signaling. Threealternatively spliced variants of this gene, which encode isoformsdiffering at their extreme C-termini, have been described. Thedifferent C-termini are thought to determine the substratespecificity, as well as the cellular localization of the isoforms.Two highly related but distinctly processed pseudogenes thatlocalize to distinct chromosomes have been reported. [provided byRefSeq].
Other Names:
Tyrosine-protein phosphatase non-receptor type 2, T-cell protein-tyrosine phosphatase, TCPTP, PTPN2, PTPT
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13311b was selected from the C-term region of PTPN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PTPN2
Gene ID: 5771
Primary Accession: P17706
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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