PTPN2 polyclonal, anti-human, rat
€388.00
In stock
SKU
BS6716
Background:
T-cell protein tyrosine phosphatase (TC-PTP) is a non-transmembrane enzyme. The noncatalytic domain of TC-PTP is alternatively spliced to generate p45TC, which localizes to the nucleus, and p48TC, which contains a hydrophobic C-terminal tail and localizes to the ER. The C-terminal segment of p45TC regulates the activity of the catalytic domain through an intramolecular interaction. The p45TC variant of TC-PTP exits the nucleus upon EGF receptor activation and recognizes the EGF receptor and p52Shc cellular substrates.
Alternative Name:
Protein tyrosine phosphatase non receptor type 2, PTN2, PTPN 2, PTPN2, PTPT, T cell protein tyrosine phosphatase, TC PTP, TCELLPTP, Tyrosine protein phosphatase non receptor type 2,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: PTPN2 polyclonal antibody detects endogenous levels of PTPN2 protein.
Immunogen:
Recombinant full length Human PTPN2.
MW: ~ 48 kDa
Swis Prot.: P17706
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
T-cell protein tyrosine phosphatase (TC-PTP) is a non-transmembrane enzyme. The noncatalytic domain of TC-PTP is alternatively spliced to generate p45TC, which localizes to the nucleus, and p48TC, which contains a hydrophobic C-terminal tail and localizes to the ER. The C-terminal segment of p45TC regulates the activity of the catalytic domain through an intramolecular interaction. The p45TC variant of TC-PTP exits the nucleus upon EGF receptor activation and recognizes the EGF receptor and p52Shc cellular substrates.
Alternative Name:
Protein tyrosine phosphatase non receptor type 2, PTN2, PTPN 2, PTPN2, PTPT, T cell protein tyrosine phosphatase, TC PTP, TCELLPTP, Tyrosine protein phosphatase non receptor type 2,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: PTPN2 polyclonal antibody detects endogenous levels of PTPN2 protein.
Immunogen:
Recombinant full length Human PTPN2.
MW: ~ 48 kDa
Swis Prot.: P17706
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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