PTPN2 polyclonal, anti-human, rat

Background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.

Synonyms: PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP

Cellular Location: Cell membrane Cytoplasm Endoplasmic reticulum Endoplasmic reticulum-Golgi intermediate compartment Nucleus

Immunogen:
Recombinant protein of human PTPN2

Gene Symbol: PTPN2

Gene ID: 5771

Swiss prot: P17706

Calculated MW: 48kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.