PTPN22 polyclonal, anti-human, mouse

Background:
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Synonyms: LYP, PEP, LYP1, LYP2, PTPN8

Cellular Location: Cytoplasm

Immunogen:
Recombinant protein of human PTPN22

Gene Symbol: PTPN22

Gene ID: 26191

Swiss prot: Q9Y2R2

Calculated MW: 92 kDa

Recommended dilution:
WB 1:200-1000, IHC 1:25-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.