PTPNS1 antibody (clone 4C7), anti-human, mouse
€435.00
In stock
SKU
AC-AT3495a
Catalog Number: AC-AT3495a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, Ehttps://www.abcepta.com/products/pdf_download/AT3495a-PTPNS1-Antibody-monoclonal-M10">Request Information AC-AT3495a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, Ehttps://www.abcepta.com/products/pdf_download/AT3495a-PTPNS1-Antibody-monoclonal-M10">Request Information AC-AT3495a">Request Information
Background:
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
Other Names:
Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Bit, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, Signal-regulatory protein alpha-2, Sirp-alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-3, p84, CD172a, SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Antigen Type:
Recombinant Protein
Gene Name: SIRPA
Gene ID: 140885
NCBI Accession: NP_001035111.1;NP_001035112.1;NP_542970.1
Primary Accession: P78324
Other Accession: BC026692
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
Other Names:
Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Bit, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, Signal-regulatory protein alpha-2, Sirp-alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-3, p84, CD172a, SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Antigen Type:
Recombinant Protein
Gene Name: SIRPA
Gene ID: 140885
NCBI Accession: NP_001035111.1;NP_001035112.1;NP_542970.1
Primary Accession: P78324
Other Accession: BC026692
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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