PTPRN2 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5871
Background:
Protein-Tyrosine Phosphatase Receptor-Type IA-2β (PTP IA-2β), alternately known as PTPRN2 or Phogrin, localizes in dense-core secretory vesicles of pancreas islet cells and influences insulin secretion. The PTP IA-2β precursor is an autoantigen that contributes to insulin-dependent diabetes mellitus (IDDM). The autoantigenic epitopes of PTP IA-2β appear within the cytoplasmic domain of this transmembrane protein. PTP IA-2β is present at high levels in brain and pancreas with lower levels in trachea, prostate, stomach and spinal cord. The human PTPRN2 gene maps to chromosome 7q36. Northern blot analysis showed that PTPRN2 was expressed as 5.5- and 3.7-kb transcripts primarily in human brain and pancreas. Three alternative transcript splice variants of this gene encode distinct proteins.
Alternative Name:
Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, KIAA0387, PTP IA-2β, PTPIA-2β, PTP-IA-2β, PTP-IA2β, PTP IA2β
Application Dilution: WB: 1:500~1:1000
Specificity: PTPRN2 polyclonal antibody detects endogenous levels of PTPRN2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 248-293 of Human PTPRN2.
MW: ~ 60, 64, 135 kDa
Swis Prot.: Q92932
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Protein-Tyrosine Phosphatase Receptor-Type IA-2β (PTP IA-2β), alternately known as PTPRN2 or Phogrin, localizes in dense-core secretory vesicles of pancreas islet cells and influences insulin secretion. The PTP IA-2β precursor is an autoantigen that contributes to insulin-dependent diabetes mellitus (IDDM). The autoantigenic epitopes of PTP IA-2β appear within the cytoplasmic domain of this transmembrane protein. PTP IA-2β is present at high levels in brain and pancreas with lower levels in trachea, prostate, stomach and spinal cord. The human PTPRN2 gene maps to chromosome 7q36. Northern blot analysis showed that PTPRN2 was expressed as 5.5- and 3.7-kb transcripts primarily in human brain and pancreas. Three alternative transcript splice variants of this gene encode distinct proteins.
Alternative Name:
Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, KIAA0387, PTP IA-2β, PTPIA-2β, PTP-IA-2β, PTP-IA2β, PTP IA2β
Application Dilution: WB: 1:500~1:1000
Specificity: PTPRN2 polyclonal antibody detects endogenous levels of PTPRN2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 248-293 of Human PTPRN2.
MW: ~ 60, 64, 135 kDa
Swis Prot.: Q92932
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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