PXF Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP2421b
Background:
The covalent attachment of prenyl lipids, such as farnesyl or geranylgeranyl groups, by specific transferases is indispensable for the cellular sorting of many proteins. Peroxisomal farnesylated protein or PXF, which localizes to the outer surface of peroxisomes, is 93% identical in sequence to human HK33, a predicted 299 amino acid protein. The ubiquitous transcription of the HK33 gene indicates its role as a housekeeping gene. At least four variants of HK33 have been identified, two of which are farnesylated in vitro. Evidence suggests that PXF is involved in the process of peroxisomal biogenesis or assembly. Complementation group J (CG-J) from patients with a peroxisome biogenesis disorder (PBD), such as Zellweger syndrome, has been identified. Human PXF expression restored peroxisomal protein import in fibroblasts from a patient with Zellweger syndrome of CG-J. This patient was homozygous for a point mutation in PXF. These results indicate that PXF is the causative gene for CG-J PBD and suggests that the C-terminal part of the PXF protein, including the CAAX homology box, is required for function.
Other Names:
Peroxisomal biogenesis factor 19, 33 kDa housekeeping protein, Peroxin-19, Peroxisomal farnesylated protein, PEX19, HK33, PXF
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2421b was selected from the C-term region of human PXF . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PEX19 (HGNC:9713)
Gene ID: 5824
Primary Accession: P40855
Other Accession: NP_001124511
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The covalent attachment of prenyl lipids, such as farnesyl or geranylgeranyl groups, by specific transferases is indispensable for the cellular sorting of many proteins. Peroxisomal farnesylated protein or PXF, which localizes to the outer surface of peroxisomes, is 93% identical in sequence to human HK33, a predicted 299 amino acid protein. The ubiquitous transcription of the HK33 gene indicates its role as a housekeeping gene. At least four variants of HK33 have been identified, two of which are farnesylated in vitro. Evidence suggests that PXF is involved in the process of peroxisomal biogenesis or assembly. Complementation group J (CG-J) from patients with a peroxisome biogenesis disorder (PBD), such as Zellweger syndrome, has been identified. Human PXF expression restored peroxisomal protein import in fibroblasts from a patient with Zellweger syndrome of CG-J. This patient was homozygous for a point mutation in PXF. These results indicate that PXF is the causative gene for CG-J PBD and suggests that the C-terminal part of the PXF protein, including the CAAX homology box, is required for function.
Other Names:
Peroxisomal biogenesis factor 19, 33 kDa housekeeping protein, Peroxin-19, Peroxisomal farnesylated protein, PEX19, HK33, PXF
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2421b was selected from the C-term region of human PXF . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PEX19 (HGNC:9713)
Gene ID: 5824
Primary Accession: P40855
Other Accession: NP_001124511
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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