GNL3L polyclonal, anti-human
€470.00
In stock
SKU
AC-AP70121
Background:
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Other Names:
GNL3L; Guanine nucleotide-binding protein-like 3-like protein
Antigen Type: synthetic peptide
Antigen Type: GNL3L
Gene ID: 54552
Primary Accession: Q9NVN8
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Other Names:
GNL3L; Guanine nucleotide-binding protein-like 3-like protein
Antigen Type: synthetic peptide
Antigen Type: GNL3L
Gene ID: 54552
Primary Accession: Q9NVN8
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