Gl Syn polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP73218
Background:
Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707).
Other Names:
GLUL; GLNS; Glutamine synthetase; GS; Glutamate decarboxylase; Glutamate--ammonia ligase
Antigen Type: synthetic peptide
Antigen Type: GLUL {ECO:0000303|PubMed:30158707, ECO:0000312|HGNC:HGNC:4341}
Gene ID: 2752
Primary Accession: P15104
Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707).
Other Names:
GLUL; GLNS; Glutamine synthetase; GS; Glutamate decarboxylase; Glutamate--ammonia ligase
Antigen Type: synthetic peptide
Antigen Type: GLUL {ECO:0000303|PubMed:30158707, ECO:0000312|HGNC:HGNC:4341}
Gene ID: 2752
Primary Accession: P15104
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