RAD17 antibody (clone 2G12), anti-human
€435.00
In stock
SKU
AC-AT3544a
Catalog Number: AC-AT3544a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E
Request Information AC-AT3544a">Request Information
Background:
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
Other Names:
Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17, R24L
Antigen Type:
Recombinant Protein
Gene Name: RAD17 {ECO:0000303|PubMed:9878245, ECO:0000312|HGNC:HGNC:9807}
Gene ID: 5884
NCBI Accession: NP_001265551.1;NP_002864.1;NP_579916.1;NP_579917.1;NP_579918.1;NP_579919.1;NP_579920.1;NP_579921.1;NP_579922.1
Primary Accession: O75943
Other Accession: BC032304
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
Other Names:
Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17, R24L
Antigen Type:
Recombinant Protein
Gene Name: RAD17 {ECO:0000303|PubMed:9878245, ECO:0000312|HGNC:HGNC:9807}
Gene ID: 5884
NCBI Accession: NP_001265551.1;NP_002864.1;NP_579916.1;NP_579917.1;NP_579918.1;NP_579919.1;NP_579920.1;NP_579921.1;NP_579922.1
Primary Accession: O75943
Other Accession: BC032304
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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