RAD17 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6669a
Background:
RAD17 is highly similar to Schizosaccharomyces pombe rad17, a cell cycle checkpoint required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells.
Other Names:
Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17, R24L
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6669a was selected from the N-term region of human RAD17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: RAD17 {ECO:0000303|PubMed:9878245, ECO:0000312|HGNC:HGNC:9807}
Gene ID: 5884
Primary Accession: O75943
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
RAD17 is highly similar to Schizosaccharomyces pombe rad17, a cell cycle checkpoint required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells.
Other Names:
Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17, R24L
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6669a was selected from the N-term region of human RAD17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: RAD17 {ECO:0000303|PubMed:9878245, ECO:0000312|HGNC:HGNC:9807}
Gene ID: 5884
Primary Accession: O75943
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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