Rad17 polyclonal, anti-human
€388.00
In stock
SKU
BS7210
Background:
DNA damage results in the arrest of cell cycle progression, allowing the damaged DNA to be repaired prior to replication. Checkpoints exist at several cell cycle phase transitions to maintain this genetic integrity. Rad9, Rad17, Rad24 and Mec3 are involved in activating the G1 and G2 checkpoints. Pol2 (also known as Dun2), encoding the catalytic subunit of DNA polymerase epsilon, plays a role in activating the S phase checkpoint. The protein kinase Rad53 (also designated Spk1, Mec2 or Sad1) is essential for both G2 and S phase arrest. Activation of Rad53 is regulated by Mec1 (also known as Esr1 and Sad3), a homolog of the human ATM protein. Pds1 and Mad2 both regulate checkpoints associated with incomplete spindle replication. Dun1, another protein kinase, plays a role in transducing the DNA damage signal.
Alternative Name:
Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17, R24L
Application Dilution: WB: 1:500 - 1:2000, IF: 1:10 - 1:100, IP: 1:50 - 1:200
Specificity: Rad17 polyclonal antibody detects endogenous levels of Rad17 protein.
Immunogen:
Recombinant full length Human Rad17.
MW: ~ 80 kDa
Swis Prot.: O75943
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
DNA damage results in the arrest of cell cycle progression, allowing the damaged DNA to be repaired prior to replication. Checkpoints exist at several cell cycle phase transitions to maintain this genetic integrity. Rad9, Rad17, Rad24 and Mec3 are involved in activating the G1 and G2 checkpoints. Pol2 (also known as Dun2), encoding the catalytic subunit of DNA polymerase epsilon, plays a role in activating the S phase checkpoint. The protein kinase Rad53 (also designated Spk1, Mec2 or Sad1) is essential for both G2 and S phase arrest. Activation of Rad53 is regulated by Mec1 (also known as Esr1 and Sad3), a homolog of the human ATM protein. Pds1 and Mad2 both regulate checkpoints associated with incomplete spindle replication. Dun1, another protein kinase, plays a role in transducing the DNA damage signal.
Alternative Name:
Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17, R24L
Application Dilution: WB: 1:500 - 1:2000, IF: 1:10 - 1:100, IP: 1:50 - 1:200
Specificity: Rad17 polyclonal antibody detects endogenous levels of Rad17 protein.
Immunogen:
Recombinant full length Human Rad17.
MW: ~ 80 kDa
Swis Prot.: O75943
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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