RAD50 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP7360a
Background:
The protein is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest RAD50 gene is essential for cell growth and viability.
Other Names:
DNA repair protein RAD50, hRAD50, 36--, RAD50
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7360a was selected from the N-term region of human RAD50. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: RAD50 {ECO:0000303|PubMed:8756642, ECO:0000312|HGNC:HGNC:9816}
Gene ID: 10111
Primary Accession: Q92878
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest RAD50 gene is essential for cell growth and viability.
Other Names:
DNA repair protein RAD50, hRAD50, 36--, RAD50
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7360a was selected from the N-term region of human RAD50. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: RAD50 {ECO:0000303|PubMed:8756642, ECO:0000312|HGNC:HGNC:9816}
Gene ID: 10111
Primary Accession: Q92878
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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