RAG2 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP12445b
Background:
This gene encodes a protein that is involved in theinitiation of V(D)J recombination during B and T cell development.This protein forms a complex with the product of the adjacentrecombination activating gene 1, and this complex can formdouble-strand breaks by cleaving DNA at conserved recombinationsignal sequences. The recombination activating gene 1 component isthought to contain most of the catalytic activity, while theN-terminal of the recombination activating gene 2 component isthought to form a six-bladed propeller in the active core thatserves as a binding scaffold for the tight association of thecomplex with DNA. A C-terminal plant homeodomain finger-like motifin this protein is necessary for interactions with chromatincomponents, specifically with histone H3 that is trimethylated atlysine 4. Mutations in this gene cause Omenn syndrome, a form ofsevere combined immunodeficiency associated with autoimmune-likesymptoms.
Other Names:
V(D)J recombination-activating protein 2, RAG-2, RAG2
Gene Name: RAG2
Gene ID: 5897
Primary Accession: P55895
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a protein that is involved in theinitiation of V(D)J recombination during B and T cell development.This protein forms a complex with the product of the adjacentrecombination activating gene 1, and this complex can formdouble-strand breaks by cleaving DNA at conserved recombinationsignal sequences. The recombination activating gene 1 component isthought to contain most of the catalytic activity, while theN-terminal of the recombination activating gene 2 component isthought to form a six-bladed propeller in the active core thatserves as a binding scaffold for the tight association of thecomplex with DNA. A C-terminal plant homeodomain finger-like motifin this protein is necessary for interactions with chromatincomponents, specifically with histone H3 that is trimethylated atlysine 4. Mutations in this gene cause Omenn syndrome, a form ofsevere combined immunodeficiency associated with autoimmune-likesymptoms.
Other Names:
V(D)J recombination-activating protein 2, RAG-2, RAG2
Gene Name: RAG2
Gene ID: 5897
Primary Accession: P55895
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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