PIF1 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP51733
Catalog Number: AC-AP54679
Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IHC-F, IF, ICC, E
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IHC-F, IF, ICC, E
Datasheet
Request Information
Background:
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
Other Names:
ATP-dependent DNA helicase PIF1 {ECO:0000255|HAMAP-Rule:MF_03176}, 36412 {ECO:0000255|HAMAP-Rule:MF_03176}, DNA repair and recombination helicase PIF1 {ECO:0000255|HAMAP-Rule:MF_03176}, PIF1/RRM3 DNA helicase-like protein, PIF1 {ECO:0000255|HAMAP-Rule:MF_03176}, C15orf20
Antigen Type: synthetic peptide
Antigen Type: PIF1 {ECO:0000255|HAMAP-Rule:MF_03176}
Gene ID: 80119
Primary Accession: Q9H611
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
Other Names:
ATP-dependent DNA helicase PIF1 {ECO:0000255|HAMAP-Rule:MF_03176}, 36412 {ECO:0000255|HAMAP-Rule:MF_03176}, DNA repair and recombination helicase PIF1 {ECO:0000255|HAMAP-Rule:MF_03176}, PIF1/RRM3 DNA helicase-like protein, PIF1 {ECO:0000255|HAMAP-Rule:MF_03176}, C15orf20
Antigen Type: synthetic peptide
Antigen Type: PIF1 {ECO:0000255|HAMAP-Rule:MF_03176}
Gene ID: 80119
Primary Accession: Q9H611
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