RanGAP1 (Ran-GTPase) Antibody (Sumoylation Site Specific) Blocking peptide
€363.00
In stock
SKU
AC-BP2503a
Background:
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
Other Names:
Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2503a was selected from the region of human Ran-GTPase Sumoylation site. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: RANGAP1
Gene ID: 5905
Primary Accession: P46060
Other Accession: NP_002874
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
Other Names:
Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2503a was selected from the region of human Ran-GTPase Sumoylation site. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: RANGAP1
Gene ID: 5905
Primary Accession: P46060
Other Accession: NP_002874
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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