RASGRP1 polyclonal, anti-human
€388.00
In stock
SKU
BS71758
Background:
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
Alternative Name:
V, RASGRP, hRasGRP1, CALDAG-GEFI, CALDAG-GEFII,
Application Dilution: WB : 1:1000 - 1:2000
Specificity: RASGRP1 polyclonal antibody detects endogenous levels of RASGRP1 protein.
Immunogen:
Recombinant protein of human RASGRP1
MW: Predicted band size: 90 kDa, Observed band size: Refer to Figures
Swis Prot.: O95267
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
Alternative Name:
V, RASGRP, hRasGRP1, CALDAG-GEFI, CALDAG-GEFII,
Application Dilution: WB : 1:1000 - 1:2000
Specificity: RASGRP1 polyclonal antibody detects endogenous levels of RASGRP1 protein.
Immunogen:
Recombinant protein of human RASGRP1
MW: Predicted band size: 90 kDa, Observed band size: Refer to Figures
Swis Prot.: O95267
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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