RASGRP4 antibody (clone 1F3), anti-human
€435.00
In stock
SKU
AC-AT3580a
Catalog Number: AC-AT3580a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, E
Request Information AC-AT3580a">Request Information
Background:
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. [provided by RefSeq]
Other Names:
RAS guanyl-releasing protein 4, RASGRP4
Antigen Type:
Recombinant Protein
Gene Name: RASGRP4
Gene ID: 115727
NCBI Accession: NP_001139674.1;NP_001139675.1;NP_001139676.1;NP_001139677.1;NP_001139678.1;NP_001139679.1;NP_733749.1
Primary Accession: Q8TDF6
Other Accession: NM_170603
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. [provided by RefSeq]
Other Names:
RAS guanyl-releasing protein 4, RASGRP4
Antigen Type:
Recombinant Protein
Gene Name: RASGRP4
Gene ID: 115727
NCBI Accession: NP_001139674.1;NP_001139675.1;NP_001139676.1;NP_001139677.1;NP_001139678.1;NP_001139679.1;NP_733749.1
Primary Accession: Q8TDF6
Other Accession: NM_170603
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
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