RASIP1 polyclonal, anti-human, rat
€305.00
In stock
SKU
BS60744
Background:
RAIN, also known as RASIP1 (Ras-interacting protein 1), is a 963 amino acid protein that contains one dilute domain and one Ras-associating domain. The RAIN protein is highly expressed in heart and detected at lower levels in placenta and pancreas. RAIN interacts with H-Ras, Rap 1A, Rap 2, R-Ras, Raf-1 and TC 21, as well as with Ras family members that have been activated by GTP binding. RAIN interacts with Ras in a GTP-dependent manner in vitro and in vivo, requiring an intact Ras core effector-binding domain for this interaction, and thus fits the definition of a Ras effector. Unlike other Ras effectors, RAIN localizes to the perinuclear, juxta-Golgi vesicles in intact cells and is recruited to the Golgi by activated Ras. Containing twelve exons, the RAIN gene is conserved in dog, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 19q13.33.
Alternative Name:
Ras-interacting protein 1, Rain, RASIP1
Application Dilution: WB: 1:500~1:1000
Specificity: RASIP1 polyclonal antibody detects endogenous levels of RASIP1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human RASIP1
MW: ~ 103 kDa
Swis Prot.: Q5U651
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
RAIN, also known as RASIP1 (Ras-interacting protein 1), is a 963 amino acid protein that contains one dilute domain and one Ras-associating domain. The RAIN protein is highly expressed in heart and detected at lower levels in placenta and pancreas. RAIN interacts with H-Ras, Rap 1A, Rap 2, R-Ras, Raf-1 and TC 21, as well as with Ras family members that have been activated by GTP binding. RAIN interacts with Ras in a GTP-dependent manner in vitro and in vivo, requiring an intact Ras core effector-binding domain for this interaction, and thus fits the definition of a Ras effector. Unlike other Ras effectors, RAIN localizes to the perinuclear, juxta-Golgi vesicles in intact cells and is recruited to the Golgi by activated Ras. Containing twelve exons, the RAIN gene is conserved in dog, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 19q13.33.
Alternative Name:
Ras-interacting protein 1, Rain, RASIP1
Application Dilution: WB: 1:500~1:1000
Specificity: RASIP1 polyclonal antibody detects endogenous levels of RASIP1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human RASIP1
MW: ~ 103 kDa
Swis Prot.: Q5U651
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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