RASSF1 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS6244
Background:
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein.
Alternative Name:
123F2, Cardiac specific ras association domain family 1 protein, NORE2A, Pancreas specific ras association domain family 1 protein, Ras association domain containing protein 1, Ras association domain family 1, Ras association domain family 1A, Ras association domain family protein 1, Ras association domain-containing protein 1, Ras association RalGDS/AF6 domain family 1, RASF1, RASSF 1, RASSF 1a, RASSF1, RASSF1A, RASSF1A isoform, RDA 32, RDA32, REH3P21, Tumor suppressor protein RDA32,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: RASSF1 polyclonal antibody detects endogenous levels of RASSF1 protein.
Immunogen:
Recombinant full length Human RASSF1.
MW: ~ 39 kDa
Swis Prot.: Q9NS23
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein.
Alternative Name:
123F2, Cardiac specific ras association domain family 1 protein, NORE2A, Pancreas specific ras association domain family 1 protein, Ras association domain containing protein 1, Ras association domain family 1, Ras association domain family 1A, Ras association domain family protein 1, Ras association domain-containing protein 1, Ras association RalGDS/AF6 domain family 1, RASF1, RASSF 1, RASSF 1a, RASSF1, RASSF1A, RASSF1A isoform, RDA 32, RDA32, REH3P21, Tumor suppressor protein RDA32,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: RASSF1 polyclonal antibody detects endogenous levels of RASSF1 protein.
Immunogen:
Recombinant full length Human RASSF1.
MW: ~ 39 kDa
Swis Prot.: Q9NS23
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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