Rb (phospho-S780) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4164
Background:
The retinoblastoma tumor suppressor gene product, known as Rb or pRb, regulates differentiation, apoptosis and cell cycle control by coordinating the cell cycle, at G1/S, with transcriptional machinery that includes the heterodimeric E2F family. During G1, cyclin D (D1, 2, 3)-dependent kinase-mediated phosphorylation of Rb at Ser 795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues, including Ser 249/Thr 252, Thr 373, Thr 356, Ser 780, Ser 807/Ser 811 and Thr 821/Thr 826.
Alternative Name:
Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1
Application Dilution: IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-Rb (S780) polyclonal antibody detects endogenous levels of Rb protein only when phosphorylated at Ser780.
Immunogen:
Synthetic phosphopeptide derived from human Rb around the phosphorylation site of Serine 780.
MW: ~ 106 kDa
Swis Prot.: P06400
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The retinoblastoma tumor suppressor gene product, known as Rb or pRb, regulates differentiation, apoptosis and cell cycle control by coordinating the cell cycle, at G1/S, with transcriptional machinery that includes the heterodimeric E2F family. During G1, cyclin D (D1, 2, 3)-dependent kinase-mediated phosphorylation of Rb at Ser 795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues, including Ser 249/Thr 252, Thr 373, Thr 356, Ser 780, Ser 807/Ser 811 and Thr 821/Thr 826.
Alternative Name:
Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1
Application Dilution: IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-Rb (S780) polyclonal antibody detects endogenous levels of Rb protein only when phosphorylated at Ser780.
Immunogen:
Synthetic phosphopeptide derived from human Rb around the phosphorylation site of Serine 780.
MW: ~ 106 kDa
Swis Prot.: P06400
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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