Rb (phospho-S811) polyclonal, anti-human

Background:
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Synonyms: OSRC, PPP1R130, RB, p105-Rb, pRb, pp110

Cellular Location: Nucleus

Immunogen:
A phospho specific peptide corresponding to residues surrounding S811 of human RB

Gene Symbol: Phospho-Rb-S811

Gene ID: 5925

Swiss prot: P06400

Calculated MW: 106kDa

Recommended dilution:
WB 1:1000-2000, IF 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.