Rb1 (Tumor Suppressor Protein) (clone SPM353), anti-human, mouse
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In stock
SKU
AC-AH13478
Catalog Number: AC-AH13478
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: SPM353
Applications: WB, IHC-P, IP
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: SPM353
Applications: WB, IHC-P, IP
Datasheet
Request Information
Background:
Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.
Other Names:
OSRC; Osteosarcoma; p105-Rb; PP105; pp110; pRb; Prepro retinoblastoma associated protein; RB1; Retinoblastoma 1; Retinoblastoma-associated protein
Antigen Type:
Recombinant protein
Gene Name: RB1
Gene ID: 5925
Primary Accession: P06400
Other Accession: 408528
Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.
Other Names:
OSRC; Osteosarcoma; p105-Rb; PP105; pp110; pRb; Prepro retinoblastoma associated protein; RB1; Retinoblastoma 1; Retinoblastoma-associated protein
Antigen Type:
Recombinant protein
Gene Name: RB1
Gene ID: 5925
Primary Accession: P06400
Other Accession: 408528
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