RBL1 Antibody(C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP19390b
Background:
The protein encoded by this gene is similar in sequenceand possibly function to the product of the retinoblastoma 1 (RB1)gene. The RB1 gene product is a tumor suppressor protein thatappears to be involved in cell cycle regulation, as it isphosphorylated in the S to M phase transition and isdephosphorylated in the G1 phase of the cell cycle. Both the RB1protein and the product of this gene can form a complex withadenovirus E1A protein and SV40 large T-antigen, with the SV40large T-antigen binding only to the unphosphorylated form of eachprotein. In addition, both proteins can inhibit the transcriptionof cell cycle genes containing E2F binding sites in theirpromoters. Due to the sequence and biochemical similarities withthe RB1 protein, it is thought that the protein encoded by thisgene may also be a tumor suppressor. Two transcript variantsencoding different isoforms have been found for this gene.
Other Names:
Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, p107, pRb1, RBL1
Gene Name: RBL1
Gene ID: 5933
Primary Accession: P28749
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is similar in sequenceand possibly function to the product of the retinoblastoma 1 (RB1)gene. The RB1 gene product is a tumor suppressor protein thatappears to be involved in cell cycle regulation, as it isphosphorylated in the S to M phase transition and isdephosphorylated in the G1 phase of the cell cycle. Both the RB1protein and the product of this gene can form a complex withadenovirus E1A protein and SV40 large T-antigen, with the SV40large T-antigen binding only to the unphosphorylated form of eachprotein. In addition, both proteins can inhibit the transcriptionof cell cycle genes containing E2F binding sites in theirpromoters. Due to the sequence and biochemical similarities withthe RB1 protein, it is thought that the protein encoded by thisgene may also be a tumor suppressor. Two transcript variantsencoding different isoforms have been found for this gene.
Other Names:
Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, p107, pRb1, RBL1
Gene Name: RBL1
Gene ID: 5933
Primary Accession: P28749
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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