Rde-1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP1964a
Background:
Double-stranded (ds) RNA is a potent sequence-specific inhibitor of gene function. RNAi (RNA interference) is a multistep process involving several proteins and small RNAs 21-25 nucleotdies in length(called siRNAs) derived from cleavage of the dsRNA trigger. Genetic studies have implicated several RNA interference-deficient (rde) family members in germline maintenance and development, and several simple loss of function mutants have been identified. Family members rde-1 and rde-4 are required for RNAi but are not essential for organismal viability. While rde-1 and rde-4 are distinct from other RNAi-deficient family members both both for their inability to mobilize transposons and lack of chromosome loss, each appears to have a different role in the interference mechanism. Evidence indicates that rde-4 is involved before or during production of siRNAs, whereas rde-1 acts after the siRNAs have been formed.
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1964a was selected from the N-term region of human Rde-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: G5EEH0
Gene ID: 179393
Primary Accession: G5EEH0
Other Accession: Q9XU82
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Double-stranded (ds) RNA is a potent sequence-specific inhibitor of gene function. RNAi (RNA interference) is a multistep process involving several proteins and small RNAs 21-25 nucleotdies in length(called siRNAs) derived from cleavage of the dsRNA trigger. Genetic studies have implicated several RNA interference-deficient (rde) family members in germline maintenance and development, and several simple loss of function mutants have been identified. Family members rde-1 and rde-4 are required for RNAi but are not essential for organismal viability. While rde-1 and rde-4 are distinct from other RNAi-deficient family members both both for their inability to mobilize transposons and lack of chromosome loss, each appears to have a different role in the interference mechanism. Evidence indicates that rde-4 is involved before or during production of siRNAs, whereas rde-1 acts after the siRNAs have been formed.
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1964a was selected from the N-term region of human Rde-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: G5EEH0
Gene ID: 179393
Primary Accession: G5EEH0
Other Accession: Q9XU82
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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