Rec.Pr.Thyrosin Phosphate (RPTP) (clone 3D7), anti-human, rat, swine
€564.00
In stock
SKU
ARP-21-5238
Catalog Number: 21-5238
Size: 100 µg
Isotype: Mouse IgG2a
Size: 100 µg
Isotype: Mouse IgG2a
Background:
Receptor-like protein tyrosine phosphatases (RPTPs) represent a new family of transmembrane proteins that are thought to transduce external signals by dephosphorylating phosphotyrosine residues on intracellular substRates. RPTPu is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions. Intracellularly, RPTPu consists of a relatively large juxtamembrane region (about 150 amino acids) and two conserved phosphatase domains. As in most RPTPs, the first (membrane-proximal) PTP domain of RPTPu is Catalytically active, whereas its second (C-terminal) domain is inactive. RPTPu is involved in cell-cell adhesion through homophilic interactions and may also play a key role in signal transduction and growth control.
Clone: 3D7
Isotype: Mouse IgG2a
Source: 3D7 is a Mouse monoclonal IgG2a antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with ExG protein, secreted by NIH-3T3 transfected cells and purified with glutahione beads. The cells have been transfected using a fusion construct, termed ExG, encoding the entire ectodomain of the Human RPTPu molecule (aa 1-742), fused COOH terminally to GST.
Reactivity: human, rat, swine
Specificity: Monoclonal antibodies 3G4 and 3D7 have been directed anti the extracellular domain of RPTPu.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
Receptor-like protein tyrosine phosphatases (RPTPs) represent a new family of transmembrane proteins that are thought to transduce external signals by dephosphorylating phosphotyrosine residues on intracellular substRates. RPTPu is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions. Intracellularly, RPTPu consists of a relatively large juxtamembrane region (about 150 amino acids) and two conserved phosphatase domains. As in most RPTPs, the first (membrane-proximal) PTP domain of RPTPu is Catalytically active, whereas its second (C-terminal) domain is inactive. RPTPu is involved in cell-cell adhesion through homophilic interactions and may also play a key role in signal transduction and growth control.
Clone: 3D7
Isotype: Mouse IgG2a
Source: 3D7 is a Mouse monoclonal IgG2a antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with ExG protein, secreted by NIH-3T3 transfected cells and purified with glutahione beads. The cells have been transfected using a fusion construct, termed ExG, encoding the entire ectodomain of the Human RPTPu molecule (aa 1-742), fused COOH terminally to GST.
Reactivity: human, rat, swine
Specificity: Monoclonal antibodies 3G4 and 3D7 have been directed anti the extracellular domain of RPTPu.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
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