Rec. Pr. Thyrosin Phosphate (RPTP) (clone 3G4), anti-human
€564.00
In stock
SKU
ARP-21-5239
Catalog Number: 21-5239
Size: 100 µg
Isotype: Mouse IgG2b
Size: 100 µg
Isotype: Mouse IgG2b
Background:
Receptor-like protein tyrosine phosphatases (RPTPs) represent a new family of transmembrane proteins that are thought to transduce external signals by dephosphorylating phosphotyrosine residues on intracellular substRates.' RPTPu is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions. Intracellularly, RPTPu consists of a relatively large juxtamembrane region (about 150 amino acids) and two conserved phosphatase domains. As in most RPTPs, the first (membrane-proximal) PTP domain of RPTPu is Catalytically active, whereas its second (C-terminal) domain is inactive. RPTPu is involved in cell-cell adhesion through homophilic interactions and may also play a key role in signal transduction and growth control.
Clone: 3G4
Isotype: Mouse IgG2b
Source: 3G4 is a Mouse monoclonal IgG2a antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with ExG protein, secreted by NIH-3T3 transfected cells and purified with glutahione beads. The cells have been transfected using a fusion construct, termed ExG, encoding the entire ectodomain of the Human RPTPu molecule (aa 1-742), fused COOH terminally to GST.
Reactivity: human
Specificity: Monoclonal antibodies 3G4 and 3D7 have been directed anti the extracellular domain of RPTPu. In the specific case of 3G4 antibodies have been raised anti the extracellular fibronectin type III repeats of Human RPTPu.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
Receptor-like protein tyrosine phosphatases (RPTPs) represent a new family of transmembrane proteins that are thought to transduce external signals by dephosphorylating phosphotyrosine residues on intracellular substRates.' RPTPu is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions. Intracellularly, RPTPu consists of a relatively large juxtamembrane region (about 150 amino acids) and two conserved phosphatase domains. As in most RPTPs, the first (membrane-proximal) PTP domain of RPTPu is Catalytically active, whereas its second (C-terminal) domain is inactive. RPTPu is involved in cell-cell adhesion through homophilic interactions and may also play a key role in signal transduction and growth control.
Clone: 3G4
Isotype: Mouse IgG2b
Source: 3G4 is a Mouse monoclonal IgG2a antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with ExG protein, secreted by NIH-3T3 transfected cells and purified with glutahione beads. The cells have been transfected using a fusion construct, termed ExG, encoding the entire ectodomain of the Human RPTPu molecule (aa 1-742), fused COOH terminally to GST.
Reactivity: human
Specificity: Monoclonal antibodies 3G4 and 3D7 have been directed anti the extracellular domain of RPTPu. In the specific case of 3G4 antibodies have been raised anti the extracellular fibronectin type III repeats of Human RPTPu.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
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