Recombinant canine IL-8/CXCL8 protein
€0.00
In stock
SKU
ATGP4043
Description
IL-8/CXCL8, also known as Interleukin-8, GCP-1, and NAP-1 is a member of the CXC family of chemokines family which is widely expressed proinflammatory. IL-8 is a potent neutrophil chemotactic factor. It attracts neutrophils, basophils, and T-cells, but not monocytes. This protein has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis, and the respiratory burst. Among the eceptors on the surface membrane capable of binding IL-8, the most frequently studied receptors are CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). Recombinant canine IL-8/CXCL8, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.Alternative Names
Interleukin-8, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8Concentration
0.25mg/ml (determined by BCA assay)Concentration
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 20% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
IL-8/CXCL8, also known as Interleukin-8, GCP-1, and NAP-1 is a member of the CXC family of chemokines family which is widely expressed proinflammatory. IL-8 is a potent neutrophil chemotactic factor. It attracts neutrophils, basophils, and T-cells, but not monocytes. This protein has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis, and the respiratory burst. Among the eceptors on the surface membrane capable of binding IL-8, the most frequently studied receptors are CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). Recombinant canine IL-8/CXCL8, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.Alternative Names
Interleukin-8, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8Concentration
0.25mg/ml (determined by BCA assay)Concentration
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 20% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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