Recombinant human Calcipressin-1/DSCR1 protein
€0.00
In stock
SKU
DSR0701
Description
The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a. Recombinant human DSCR1 was expressed in E. coli and purified by using conventional chromatography techniques.Alternative Names
Calcipressin 1 isoform b, Regulator of calcineurin 1, RCAN1, Down syndrome critical region gene 1, DSCR1, Adapt78, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, CSP1, DSC1Concentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl, 1mM DTT, 10% GlycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a. Recombinant human DSCR1 was expressed in E. coli and purified by using conventional chromatography techniques.Alternative Names
Calcipressin 1 isoform b, Regulator of calcineurin 1, RCAN1, Down syndrome critical region gene 1, DSCR1, Adapt78, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, CSP1, DSC1Concentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl, 1mM DTT, 10% GlycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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