Recombinant human CD158e/KIR3DL1 protein
€0.00
In stock
SKU
KIR3004
Description
The three Ig-domain from of inhibitory killer cell Ig-like receptor 1 (KIR3DL1, NKB1, nkat3, p70KIR) is a NK cell receptor for polymorphic HLA-B determinant. KIR3DL1 recognizes the Bw4 determinant defined by sequence motifs at positins 77-83 of the HLA-B heavy chain. The cytoplasmic tail of KIR, which contains two immunoreceptor tyrosine-based inhibition motifs (ITIMs), mediates inhibitory signal transduction that prevents killer cell-mediated cytotoxicity. A His-tag fusion protein of KIR3DL1 cytoplasmic tail (361-444aa) was overexpressed as insoluble protein aggregates (inclusion bodies). This protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox bufferAlternative Names
Killer cell immunoglobulin like receptor three Ig domains and long cytoplasmic tail 1, CD158 antigen-like family member E, HLA-BW4-specific inhibitory NK cell receptor, Natural killer-associated transcript 3, NKAT-3, p70 natural killer cell receptor clones CL-2/CL-11, p70 NK receptor CL-2/CL-11, cl-2, KIR, NKB1, cl-11, NKB1B, AMB11, CD158e1/2, CD158E1, CD158e2Concentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. 25mM Tris-HCl buffer (pH 7.5) containing 100mM NaClStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
The three Ig-domain from of inhibitory killer cell Ig-like receptor 1 (KIR3DL1, NKB1, nkat3, p70KIR) is a NK cell receptor for polymorphic HLA-B determinant. KIR3DL1 recognizes the Bw4 determinant defined by sequence motifs at positins 77-83 of the HLA-B heavy chain. The cytoplasmic tail of KIR, which contains two immunoreceptor tyrosine-based inhibition motifs (ITIMs), mediates inhibitory signal transduction that prevents killer cell-mediated cytotoxicity. A His-tag fusion protein of KIR3DL1 cytoplasmic tail (361-444aa) was overexpressed as insoluble protein aggregates (inclusion bodies). This protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox bufferAlternative Names
Killer cell immunoglobulin like receptor three Ig domains and long cytoplasmic tail 1, CD158 antigen-like family member E, HLA-BW4-specific inhibitory NK cell receptor, Natural killer-associated transcript 3, NKAT-3, p70 natural killer cell receptor clones CL-2/CL-11, p70 NK receptor CL-2/CL-11, cl-2, KIR, NKB1, cl-11, NKB1B, AMB11, CD158e1/2, CD158E1, CD158e2Concentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. 25mM Tris-HCl buffer (pH 7.5) containing 100mM NaClStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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