Recombinant human CD72 protein
€0.00
In stock
SKU
ATGP3869
Description
CD72, also known as B-cell differentiation antigen CD72, is a type II transmembrane glycoprotein carrying a C-type lectin domain. It plays a role in immune system regulation of animals and expressed on B lineage cells, NK cells, monocytes, dendritic cells, and mast cells as a homodimer. Also, this protein associates with CD79A in the B cell antigen receptor (BCR) complex following antigen stimulation and dampens BCR signaling through interactions with the phosphatase SHP1. It binding to Semaphorin 4D induces cytokine production by monocytes and dendritic cells, inhibits SCF R/ckit induced mast cell proliferation and activation, and inhibits the cytolytic activity of NK cells. Moreover, BCR signaling enhances phosphorylation of CD72 and its recruitment of SHP-1. Recombinant human CD72, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
CD72, CD72b, LYB2, B-cell differentiation antigen CD72, Lyb-2, CD_antigen: CD72Concentration
0.5mg/ml (determined by absorbance at 280nm)Concentration
Liquid in. 50mM Tris-HCl buffer (pH 6.8) containing 2mM DTT, 0.2M NaCl, 50% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
CD72, also known as B-cell differentiation antigen CD72, is a type II transmembrane glycoprotein carrying a C-type lectin domain. It plays a role in immune system regulation of animals and expressed on B lineage cells, NK cells, monocytes, dendritic cells, and mast cells as a homodimer. Also, this protein associates with CD79A in the B cell antigen receptor (BCR) complex following antigen stimulation and dampens BCR signaling through interactions with the phosphatase SHP1. It binding to Semaphorin 4D induces cytokine production by monocytes and dendritic cells, inhibits SCF R/ckit induced mast cell proliferation and activation, and inhibits the cytolytic activity of NK cells. Moreover, BCR signaling enhances phosphorylation of CD72 and its recruitment of SHP-1. Recombinant human CD72, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
CD72, CD72b, LYB2, B-cell differentiation antigen CD72, Lyb-2, CD_antigen: CD72Concentration
0.5mg/ml (determined by absorbance at 280nm)Concentration
Liquid in. 50mM Tris-HCl buffer (pH 6.8) containing 2mM DTT, 0.2M NaCl, 50% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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