Recombinant human Complement Factor B protein
€0.00
In stock
SKU
ATGP3903
Description
Complement factor B, also known as CFB, is a component of the alternative pathway of complement activation.Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, itis cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The activesubunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb isinvolved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. Recombinant human Complement factor B protein, fused to His-tag at C-terminus, was expressed in insect cell and purified byusing conventional chromatography techniques.Alternative Names
CFB, C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, BF, BFD, AHUS4, ARMD14, CFAB, CFBD, FB, FBI12, GBG, H2-BfConcentration
0.5mg/ml (determined by absorbance at 280nm)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Complement factor B, also known as CFB, is a component of the alternative pathway of complement activation.Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, itis cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The activesubunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb isinvolved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. Recombinant human Complement factor B protein, fused to His-tag at C-terminus, was expressed in insect cell and purified byusing conventional chromatography techniques.Alternative Names
CFB, C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, BF, BFD, AHUS4, ARMD14, CFAB, CFBD, FB, FBI12, GBG, H2-BfConcentration
0.5mg/ml (determined by absorbance at 280nm)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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