Recombinant human ErbB2/Her2 protein
€0.00
In stock
SKU
ATGP3586
Description
ERBB2, also known as receptor tyrosine-protein kinase erbB-2 isoform, belongs to the epidermal growth factor (EGF) receptor family. It is an oncogene encoding a type 1 tyrosine kinase growth factor receptor. Its overexpression is associated with reduced disease free and overall survival. It is a predictor factor for poor response to chemotherapy and plays a key role in development, cell proliferation and differentiation. It is permanently coupled to phospholipase C gamma and involves tyrosine phosphorylation and activation of PLC gamma. It reflects the molecular biological properties of gastric cancer and may be clinically used to determine indications for the use of targeted drugs. It results in cellular transformation and is associated with a variety of malignancy and breast, prostate, ovarian, lung cancers. Recombinant human ERBB2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
Receptor tyrosine-protein kinase erbB-2 isoform, ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1Concentration
0.25mg/ml (determined by Bradford assay)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
ERBB2, also known as receptor tyrosine-protein kinase erbB-2 isoform, belongs to the epidermal growth factor (EGF) receptor family. It is an oncogene encoding a type 1 tyrosine kinase growth factor receptor. Its overexpression is associated with reduced disease free and overall survival. It is a predictor factor for poor response to chemotherapy and plays a key role in development, cell proliferation and differentiation. It is permanently coupled to phospholipase C gamma and involves tyrosine phosphorylation and activation of PLC gamma. It reflects the molecular biological properties of gastric cancer and may be clinically used to determine indications for the use of targeted drugs. It results in cellular transformation and is associated with a variety of malignancy and breast, prostate, ovarian, lung cancers. Recombinant human ERBB2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
Receptor tyrosine-protein kinase erbB-2 isoform, ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1Concentration
0.25mg/ml (determined by Bradford assay)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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