Recombinant human FGF-8b protein
€0.00
In stock
SKU
ATGP4097
Description
FGF-8b, also known as Fibroblast growth factor 8 isoform B, is a member of the fibroblast growth factor (FGF) family that plays a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF-8; FGF-8a, FGF-8b, FGF-8e and FGF-8f. FGF-8 is widely expressed during embryogenesis, and mediates epithelial-mesenchymal transitions. It encodes a key signaling factor, and its precise regulation is essential for embryo patterning. FGF-8b shows the strongest receptor affinity and oncogenic transforming capacity. FGF-8 signaling from the apical ectodermal ridge (AER), which borders the distal end of the limb bud, is necessary for forming normal limbs. FGF-8 is responsible for cell proliferation and survival, as well. The ability for FGF-8 to regulate cell proliferation has caused interest in its effects on tumors or squamous cell carcinoma. Recombinant human FGF-8b, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.Alternative Names
FGF8, AIGF, Androgen-induced growth factor, FGF-8, HBGF-8, Heparin-binding growth factor 8, HH6, KAL6,fibroblast growth factor 8, fibroblast growth factor 8 isoform BConcentration
0.25 mg/ml (determined by Absorbance at 280nm)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol.Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
FGF-8b, also known as Fibroblast growth factor 8 isoform B, is a member of the fibroblast growth factor (FGF) family that plays a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF-8; FGF-8a, FGF-8b, FGF-8e and FGF-8f. FGF-8 is widely expressed during embryogenesis, and mediates epithelial-mesenchymal transitions. It encodes a key signaling factor, and its precise regulation is essential for embryo patterning. FGF-8b shows the strongest receptor affinity and oncogenic transforming capacity. FGF-8 signaling from the apical ectodermal ridge (AER), which borders the distal end of the limb bud, is necessary for forming normal limbs. FGF-8 is responsible for cell proliferation and survival, as well. The ability for FGF-8 to regulate cell proliferation has caused interest in its effects on tumors or squamous cell carcinoma. Recombinant human FGF-8b, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.Alternative Names
FGF8, AIGF, Androgen-induced growth factor, FGF-8, HBGF-8, Heparin-binding growth factor 8, HH6, KAL6,fibroblast growth factor 8, fibroblast growth factor 8 isoform BConcentration
0.25 mg/ml (determined by Absorbance at 280nm)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol.Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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