Recombinant human Hexosaminidase A/HEXA protein
€0.00
In stock
SKU
ATGP1941
Description
HEXA is the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). Recombinant human HEXA protein, fused to His-tag at N-terminus, was expressed in E. coli.Alternative Names
beta-hexosaminidase subunit alpha, TSD, hexosaminidase AConcentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
HEXA is the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). Recombinant human HEXA protein, fused to His-tag at N-terminus, was expressed in E. coli.Alternative Names
beta-hexosaminidase subunit alpha, TSD, hexosaminidase AConcentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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