Recombinant human IL-19 protein
€0.00
In stock
SKU
ATGP4024
Description
IL-19, also known as Interleukin-19, is a member of the IL-10 family of related cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. This protein is an immunosuppressive cytokine that is responsible for both cell type-specific and system-specific down-regulation of inflammation, because it up-regulates IL-6 and TNF-α, and induces apoptosis through TNF-α. It binds a receptor complex consisting of the IL-20 receptor alpha (IL-20 R1) and the IL-20 receptor beta (IL-20 R2). This receptor complex is also shared by IL-20 and IL-24. IL-19-deficient animals was associated with reduced numbers of IL-6-producing macrophages in the inflamed colonic lamina propria. It may contribute to the pathogenesis of inflammatory bowel disease. Recombinant human IL-19, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.Alternative Names
Interleukin-19, IL-19, Melanoma differentiation-associated protein-like protein, NG.1, ZMDA1, MDA1, IL-10C, IL19, Interleukin19, Macrophagleukin-19, IL-19, 2Concentration
0.5mg/ml (determined by absorbance at 280nm)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
IL-19, also known as Interleukin-19, is a member of the IL-10 family of related cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. This protein is an immunosuppressive cytokine that is responsible for both cell type-specific and system-specific down-regulation of inflammation, because it up-regulates IL-6 and TNF-α, and induces apoptosis through TNF-α. It binds a receptor complex consisting of the IL-20 receptor alpha (IL-20 R1) and the IL-20 receptor beta (IL-20 R2). This receptor complex is also shared by IL-20 and IL-24. IL-19-deficient animals was associated with reduced numbers of IL-6-producing macrophages in the inflamed colonic lamina propria. It may contribute to the pathogenesis of inflammatory bowel disease. Recombinant human IL-19, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.Alternative Names
Interleukin-19, IL-19, Melanoma differentiation-associated protein-like protein, NG.1, ZMDA1, MDA1, IL-10C, IL19, Interleukin19, Macrophagleukin-19, IL-19, 2Concentration
0.5mg/ml (determined by absorbance at 280nm)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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