Recombinant human IL-4I1 protein
€0.00
In stock
SKU
ATGP4099
Description
IL-4I1, also known as FIG1, is a secreted L-amino-acid oxidase that acts as a key immunoregulator. It is highly expressed in primary metastinal B-cell lymphomas. This protein acts as a negative regultaotr of anti-tumor immunity by mediating Trp degradation via ans indole pyruvate pathway that activates the transcription factor AHR. IL-4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer. IL-41I also regulates M2 macrophage polarization by inhibiting T-cell activation and has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4+ and H2O2. Recombinant human IL-4I1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
Interleukin 4 induced 1, FIG1, LAAO, LAO, L-amino-acid oxidase isoform 1, L-amino-acid oxidase, IL4-induced protein 1, Fig-1, IL4I1, hIL4I1Concentration
0.25mg/ml (determined by Absorbance at 280nm)Concentration
Liquid in. 20mM MES (pH5.5) containing 0.1M NaCl, 40% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
IL-4I1, also known as FIG1, is a secreted L-amino-acid oxidase that acts as a key immunoregulator. It is highly expressed in primary metastinal B-cell lymphomas. This protein acts as a negative regultaotr of anti-tumor immunity by mediating Trp degradation via ans indole pyruvate pathway that activates the transcription factor AHR. IL-4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer. IL-41I also regulates M2 macrophage polarization by inhibiting T-cell activation and has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4+ and H2O2. Recombinant human IL-4I1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
Interleukin 4 induced 1, FIG1, LAAO, LAO, L-amino-acid oxidase isoform 1, L-amino-acid oxidase, IL4-induced protein 1, Fig-1, IL4I1, hIL4I1Concentration
0.25mg/ml (determined by Absorbance at 280nm)Concentration
Liquid in. 20mM MES (pH5.5) containing 0.1M NaCl, 40% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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