Recombinant human OX40 Ligand/TNFSF4 protein
€0.00
In stock
SKU
ATGP4136
Description
OX40 Ligand/TNFSF4, also known as Inositol monophosphatase 3, is a member of the tumor necrosis factor (TNF) receptor family. It is expressed on many antigen-presenting cells such as DC2s, macrophages, and activated B lymphocytes. The receptor for OX40L is OX40 that is expressed predominantly on activated CD4+ T cells. Expression of OX40 is transient following engagement of T cell receptors. The ligation of OX40-OX40L is a source of survival signal for T cells and enables the development of memory T cells. Also, It stimulates proliferation and differentiation of activated B cells, and increases immunoglobulin secretion. OX40-OX40 Ligand signaling is involved in graft-versus-host disease and autoimmune disease . Mutations in OX40 and OX40 Ligand are associated with cardiovascular disease. Recombinant human OX40 Ligand/TNFSF4, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.Alternative Names
Tumor necrosis factor superfamily member 4 isoform 1, Glycoprotein Gp34, TAX transcriptionally-activated glycoprotein 1, Ath1, Ath-1, CD134L, OX40 ligand, OX40L, 34kD taxtranscriptionally activated glycoprotein 1, gp34, TXGP1, Txgp1l, TNLG2B, CD252, TNFSF4Concentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
OX40 Ligand/TNFSF4, also known as Inositol monophosphatase 3, is a member of the tumor necrosis factor (TNF) receptor family. It is expressed on many antigen-presenting cells such as DC2s, macrophages, and activated B lymphocytes. The receptor for OX40L is OX40 that is expressed predominantly on activated CD4+ T cells. Expression of OX40 is transient following engagement of T cell receptors. The ligation of OX40-OX40L is a source of survival signal for T cells and enables the development of memory T cells. Also, It stimulates proliferation and differentiation of activated B cells, and increases immunoglobulin secretion. OX40-OX40 Ligand signaling is involved in graft-versus-host disease and autoimmune disease . Mutations in OX40 and OX40 Ligand are associated with cardiovascular disease. Recombinant human OX40 Ligand/TNFSF4, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.Alternative Names
Tumor necrosis factor superfamily member 4 isoform 1, Glycoprotein Gp34, TAX transcriptionally-activated glycoprotein 1, Ath1, Ath-1, CD134L, OX40 ligand, OX40L, 34kD taxtranscriptionally activated glycoprotein 1, gp34, TXGP1, Txgp1l, TNLG2B, CD252, TNFSF4Concentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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