Recombinant human REF-1/APEX1 protein
€0.00
In stock
SKU
ATGP0881
Description
APEX1, also known as REF1 or APE1 (Apurinic / apyrimidinic endonuclease), is responsible for the incision of DNA basic sites during base excision repair. It has also been shown to stimulate the DNA binding activity of numerous transcription factors that are involved in cancer promotion and progression. APEX1 is part of the cellular response to oxidative stress and protects cells from the genotoxic and cytotoxic effect of oxidizing agents. Recombinant human APEX1 protein, fused to T7-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.Alternative Names
Apurinic/apyrimidinic endodeoxyribonuclease 1, APEX nuclease, APEN, multifunctional DNA repair enzyme 1, DNA-(apurinic or apyrimidinic site) endonuclease, AP endonuclease 1, APE-1, Redox factor-1, APE, APE1, APEX, APX, HAP1, REF1Concentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 2mM DTT, 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
APEX1, also known as REF1 or APE1 (Apurinic / apyrimidinic endonuclease), is responsible for the incision of DNA basic sites during base excision repair. It has also been shown to stimulate the DNA binding activity of numerous transcription factors that are involved in cancer promotion and progression. APEX1 is part of the cellular response to oxidative stress and protects cells from the genotoxic and cytotoxic effect of oxidizing agents. Recombinant human APEX1 protein, fused to T7-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.Alternative Names
Apurinic/apyrimidinic endodeoxyribonuclease 1, APEX nuclease, APEN, multifunctional DNA repair enzyme 1, DNA-(apurinic or apyrimidinic site) endonuclease, AP endonuclease 1, APE-1, Redox factor-1, APE, APE1, APEX, APX, HAP1, REF1Concentration
1mg/ml (determined by Bradford assay)Concentration
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 2mM DTT, 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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