Recombinant human Serpin G1/SERPING1 protein
€0.00
In stock
SKU
ATGP3829
Description
SERPING1, also known as plasma protease C1 inhibitor, is a protease inhibitor belonging to the serpin superfamily. This protein is the physiological inhibitor of activated C1r and C1s, two serine proteases involved in the classical complement pathway. Also, it has a 2-domain structure, unlike most family members. The C-terminal serpin domain is similar to other serpins, and this part of this inhibitor provides the inhibitory activity. C1-inhibitor is highly glycosylated, bearing both N- and O-glycans. Deficiency of this protein results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa. It is an attractive therapeutic protein to treat inflammatory diseases other than HAE. Recombinant human SERPING1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
Serpin family G member 1, C1NH, C1 Inh, C1 esterase inhibitor, C1-inhibiting factor, HAE1, HAE2, Plasma protease C1 inhibitor, C1-inhibitorConcentration
1mg/ml (determined by absorbance at 280nm)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
SERPING1, also known as plasma protease C1 inhibitor, is a protease inhibitor belonging to the serpin superfamily. This protein is the physiological inhibitor of activated C1r and C1s, two serine proteases involved in the classical complement pathway. Also, it has a 2-domain structure, unlike most family members. The C-terminal serpin domain is similar to other serpins, and this part of this inhibitor provides the inhibitory activity. C1-inhibitor is highly glycosylated, bearing both N- and O-glycans. Deficiency of this protein results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa. It is an attractive therapeutic protein to treat inflammatory diseases other than HAE. Recombinant human SERPING1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.Alternative Names
Serpin family G member 1, C1NH, C1 Inh, C1 esterase inhibitor, C1-inhibiting factor, HAE1, HAE2, Plasma protease C1 inhibitor, C1-inhibitorConcentration
1mg/ml (determined by absorbance at 280nm)Concentration
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerolStorage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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